Only thing that might not work is tv-out.I have not tried it.

Mepis recognizes only one processor, while I have a dual-core, I do not really care.
DVD+rw is spinning too fast when inserted.
I had also problems with burning data (iso, movies) on dvd in k3b. maybe trying a different program solves the problem, because I could burn cd's(audio-cd and iso)
These are minor issues you do not even notice while operating. I can live with it.

Soundcard, headphones, motherboard, wifi are working fine.