The USB Overdrive is a device driver for Mac OS X that handles any USB mouse / trackball / joystick / gamepad / media keyboard and any Bluetooth mouse from any manufacturer and lets you configure them either globally or on a per-application, per-device basis.

It reads all kinds of wheels, buttons, switches and controls and assigns them to useful actions like clicking, typing, scrolling, launching, opening documents and so forth. The USB Overdrive can easily handle several USB devices at once and can assign different settings to each one.

Requirements:
OS X 10.11+
64-bit Intel

Also available are:
Version 3.2 for OS X 10.8-11
Version 3.0.2 for OS X 10.6-10.7
Version 3.0.1 for OS X 10.4-10.5
Version 10.4.8 for OS X 10.2.8-10.3